Micronutrients
Vitamin D is not a vitamin. It is a secosteroid hormone acting through a nuclear receptor — which is why 'just take more' is the wrong frame.
Not yet investigated
Vitamin D is not a vitamin. It is a secosteroid hormone acting through a nuclear receptor — which is why 'just take more' is the wrong frame.
This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.
What we are reading
Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
Calcitriol is 1,25(OH)2D3, the end of the activation chain and the molecule that actually does the work through VDR/RXR. Extraskeletal effects reported in knockout and transgenic mice — cancer progression, cardiovascular, immunomodulation in autoimmune disease — with the authors noting only that SOME have also been observed in humans. The gap between mouse mechanism and human outcome is the whole vitamin D supplement debate.
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Also in Micronutrients
The letter
The full citation list for each investigation, the studies that didn't make the episode, and any corrections — sent the morning it publishes.
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