Micronutrients
Myo- and D-chiro-inositol shift insulin resistance and ovulation in PCOS trials — one of the few supplements with both a mechanism and a signal.
Not yet investigated
Myo- and D-chiro-inositol shift insulin resistance and ovulation in PCOS trials — one of the few supplements with both a mechanism and a signal.
This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.
What we are reading
Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
26 RCTs, 1691 women. The strongest integrative result in this set: inositol raised the chance of a regular cycle 1.79-fold over placebo and was NON-INFERIOR to metformin, the gold-standard insulin sensitiser, while also lowering BMI, free and total testosterone, androstenedione, glucose and insulin AUC and raising SHBG. The clinical argument is the side-effect profile — metformin's gastrointestinal effects are why people stop taking it. Note what this does NOT show: no fertility or live-birth outcome, and 'non-inferior' is not 'better'.
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The letter
The full citation list for each investigation, the studies that didn't make the episode, and any corrections — sent the morning it publishes.
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