Micronutrients
Matrix Gla protein needs it for carboxylation; trials show no slower calcification.
Not yet investigated
Matrix Gla protein needs it for carboxylation; trials show no slower calcification.
This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.
What we are reading
Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
A clean NULL in Circulation, and the most instructive result in this batch. 365 men, 720 µg MK-7 plus vitamin D or placebo, two years. Aortic valve calcification progressed by 275 AU on treatment versus 292 on placebo — no difference. No difference in valve area, jet velocity, aortic or coronary calcification, surgery, death or cardiovascular events. AND YET the biomarker worked exactly as the theory predicted: dp-ucMGP fell sharply on MK-7. The carboxylation mechanism is real; the disease did not care. Anyone selling K2 for arterial calcification has to answer this trial.
Connected on the map
Also in Micronutrients
The letter
The full citation list for each investigation, the studies that didn't make the episode, and any corrections — sent the morning it publishes.
No sponsors · No supplement affiliates · Unsubscribe any time
