Micronutrients
Fat-soluble thiamine crosses membranes the water-soluble salt cannot. The real question is who is actually deficient, not who feels tired.
Not yet investigated
Fat-soluble thiamine crosses membranes the water-soluble salt cannot. The real question is who is actually deficient, not who feels tired.
This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.
What we are reading
Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
CAREFUL: this reviews BENFOTIAMINE, a different lipid-soluble thiamine derivative from allithiamine/TTFD. It is here for the mechanism the two share and for the fact that a derivative was needed at all — benfotiamine activates transketolase and thereby diverts glucose away from the polyol, hexosamine, protein-kinase-C and advanced-glycation pathways. That is the pharmacological case for the derivatives over plain thiamine. Do not let the episode slide from benfotiamine evidence to allithiamine claims; TTFD needs its own trials cited.
Connected on the map
Also in Micronutrients
The letter
The full citation list for each investigation, the studies that didn't make the episode, and any corrections — sent the morning it publishes.
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