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Immune

Innate immunity

Most cold symptoms come from the host response, not from the virus itself.

Filed under Concept Constellation Immune Status Upcoming

Not yet investigated

What we have so far

Most cold symptoms come from the host response, not from the virus itself.

This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.

What we are reading

Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.

  1. Bekkering S, Blok BA, Joosten LAB, Riksen NP, van Crevel R, Netea MG. In vitro experimental model of trained innate immunity in human primary monocytes.Clin Vaccine Immunol · 2016 · 23(12):926–93310.1128/CVI.00349-16 · PMID 27733422

    IN VITRO, human primary monocytes — a methods paper, not a clinical result. Worth having because it pins down what 'trained immunity' actually means physically: β-glucan, BCG and oxidised LDL all leave monocytes responding harder to unrelated bacteria days later, with a switch to glycolysis. Innate immunity having memory at all is the part that overturns the textbook.

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The letter

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The full citation list for each investigation, the studies that didn't make the episode, and any corrections — sent the morning it publishes.

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