Micronutrients
Metformin lowers its absorption, and the deficiency mimics the neuropathy of diabetes.
Not yet investigated
Metformin lowers its absorption, and the deficiency mimics the neuropathy of diabetes.
This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.
What we are reading
Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
No DOI on this one. Practical and specific about who is actually at risk: gastric or small-bowel resection, IBD, METFORMIN for more than four months, PPIs or H2 blockers for more than twelve, vegans and strict vegetarians, and anyone over 75. Two things worth saying on air: serum B12 alone is unreliable, and methylmalonic acid is what confirms deficiency at low-normal levels; and ORAL high-dose B12 (1–2 mg daily) matches intramuscular for correcting both anaemia and neurological symptoms, which contradicts the received wisdom that injections are necessary.
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Also in Micronutrients
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The full citation list for each investigation, the studies that didn't make the episode, and any corrections — sent the morning it publishes.
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