Micronutrients
Metformin inhibits the transporter that absorbs it; the clinical evidence is thinner.
Not yet investigated
Metformin inhibits the transporter that absorbs it; the clinical evidence is thinner.
This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.
What we are reading
Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
Mayo Clinic Proceedings, and quietly damning about ordinary practice. The classic triad — confusion, eye signs, gait — is complete in only 10% of cases, and only a few cases are diagnosed BEFORE DEATH. Untreated, about 80% go on to Korsakoff syndrome. Their recommendation is that overdiagnosis and overtreatment are preferable given thiamine's excellent safety profile. Also worth saying on air: alcohol is the commonest cause in the US but hyperemesis gravidarum, bowel obstruction and malignancy all do it too, which is how it gets missed.
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Also in Micronutrients
The letter
The full citation list for each investigation, the studies that didn't make the episode, and any corrections — sent the morning it publishes.
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