Inflammation induces IDO, which pulls tryptophan away from serotonin.
Filed under PathwayConstellation Mood & neurochemistryStatus Upcoming
Not yet investigated
What we have so far
Inflammation induces IDO, which pulls tryptophan away from serotonin.
This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.
What we are reading
Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
Correia AS, Vale N. Tryptophan metabolism in depression: a narrative review with a focus on serotonin and kynurenine pathways.Int J Mol Sci · 2022 · 23(15):849310.3390/ijms23158493 · PMID 35955633
Narrative review. Places the kynurenine branch at the junction of neuroinflammation, stress, the microbiota and BDNF regulation. Needs primary trial evidence alongside it before any claim that shifting this pathway changes symptoms.