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Mood & neurochemistry

Abeta*56

The 2006 oligomer that shaped a field. The paper was retracted in 2024 after its images were found to have been altered.

Filed under Finding Constellation Mood & neurochemistry Status Upcoming

Not yet investigated

What we have so far

The 2006 oligomer that shaped a field. The paper was retracted in 2024 after its images were found to have been altered.

This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.

What we are reading

Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.

  1. Lesné S, Koh MT, Kotilinek L, et al. A specific amyloid-beta protein assembly in the brain impairs memory. [RETRACTED]Nature · 2006 · 440(7082):352–357 · retracted 202410.1038/nature04533 · PMID 16541076

    PubMed itself classifies this paper as a Retracted Publication — that is checkable in one click and is how the episode should source the claim, rather than by citing journalism about it. The original claim: a 56-kDa soluble assembly, Abeta*56, purified from Tg2576 mouse brain impaired memory in young rats INDEPENDENTLY of plaques or neuron loss. It ran for 16 years and shaped a field. Retracted in 2024 after image alteration. Precision matters here: what was retracted is this specific oligomer result, not the existence of amyloid plaques, which have been observable pathology since 1906.

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