Mood & neurochemistry
Tangles track cognitive decline better than plaques do, which has always been an awkward fact for the amyloid story.
Not yet investigated
Tangles track cognitive decline better than plaques do, which has always been an awkward fact for the amyloid story.
This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.
What we are reading
Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
Standard review, useful for defining terms on air without jargon. Two hallmarks, two different proteins: neuritic PLAQUES are extracellular amyloid-beta; neurofibrillary TANGLES are intracellular, and are cytoskeletal damage caused by hyperphosphorylation of the microtubule-associated protein tau. Conflating them is the commonest error in popular coverage. Also lays out the three clinical phases — pre-symptomatic, pre-dementia, dementia — which is why 'early intervention' arguments carry so much weight.
Connected on the map
Also in Mood & neurochemistry
The letter
The full citation list for each investigation, the studies that didn't make the episode, and any corrections — sent the morning it publishes.
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