Gut & microbiome
Ninety per cent is made in the gut, and that fraction never reaches the brain.
Not yet investigated
Ninety per cent is made in the gut, and that fraction never reaches the brain.
This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.
What we are reading
Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
The landmark, from Mazmanian's lab. Spore-forming gut bacteria drive 5-HT synthesis in colonic enterochromaffin cells, which supply the mucosa, the lumen and circulating platelets — and germ-free mice given the right microbial metabolites raise their colonic and blood serotonin. MOUSE work with human-derived bacteria. The honest framing for air: this is where 'the gut makes most of your serotonin' stops being a slogan and becomes a mechanism, but it is gut serotonin, which does not cross into the brain.
Connected on the map
Also in Gut & microbiome
The letter
The full citation list for each investigation, the studies that didn't make the episode, and any corrections — sent the morning it publishes.
No sponsors · No supplement affiliates · Unsubscribe any time
