Gut & microbiome
Butyrate, propionate, acetate — the cells lining the colon run mostly on the first.
Not yet investigated
Butyrate, propionate, acetate — the cells lining the colon run mostly on the first.
This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.
What we are reading
Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
MOUSE macrophages in culture — narrow, and a better human source should replace it. Kept for two things it states directly: butyrate comes from bacterial fermentation of dietary fibre and is the PRIMARY energy source of colonocytes, and it acts on immune cells partly by inhibiting histone deacetylation. A fibre metabolite changing gene expression is the mechanism worth an episode.
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The full citation list for each investigation, the studies that didn't make the episode, and any corrections — sent the morning it publishes.
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