Gut & microbiome
Much of the leaky-gut literature rests on a zonulin ELISA that does not measure zonulin.
Not yet investigated
Much of the leaky-gut literature rests on a zonulin ELISA that does not measure zonulin.
This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.
What we are reading
Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
The measurement problem, which is the real story under 'leaky gut'. Against the established lactulose/mannitol test in 78 people, plasma LBP tracked permeability in every cohort — but ZONULIN, the marker sold direct to consumers, only correlated in the overweight and obese group, and only when measured in stool. A zonulin result in a lean person is being asked to carry more than this data supports.
Connected on the map
Also in Gut & microbiome
The letter
The full citation list for each investigation, the studies that didn't make the episode, and any corrections — sent the morning it publishes.
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