Detergents that also act as hormones, and gut bacteria rewrite them en route.
Filed under CompoundConstellation Gut & microbiomeStatus Upcoming
Not yet investigated
What we have so far
Detergents that also act as hormones, and gut bacteria rewrite them en route.
This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.
What we are reading
Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
Jia W, Xie G, Jia W. Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis.Nat Rev Gastroenterol Hepatol · 2018 · 15(2):111–12810.1038/nrgastro.2017.119 · PMID 29018272
Review. The useful frame for this node: bile acids are not just detergents for fat, they are SIGNALS, read by FXR and TGR5, and gut bacteria chemically rewrite them before the host receives them. That makes bile acid metabolism a two-way conversation between liver and microbiome that touches lipid and carbohydrate handling, insulin sensitivity and innate immunity.