Narcolepsy type 1 is the loss of these neurons; the newest sleep drugs block their receptors.
Filed under CompoundConstellation Sleep & circadianStatus Upcoming
Not yet investigated
What we have so far
Narcolepsy type 1 is the loss of these neurons; the newest sleep drugs block their receptors.
This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.
What we are reading
Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
Jacobson LH, Hoyer D, de Lecea L. Hypocretins (orexins): The ultimate translational neuropeptides.J Intern Med · 2022 · 291(5):533–55610.1111/joim.13406 · PMID 35043499
Review. Confirms both halves of the node: loss of hypocretin cells in humans causes narcolepsy type 1 with cataplexy, and that causal link produced a drug class — suvorexant and lemborexant approved for insomnia, daridorexant then filed.