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Sleep & circadian

Orexin

Narcolepsy type 1 is the loss of these neurons; the newest sleep drugs block their receptors.

Filed under Compound Constellation Sleep & circadian Status Upcoming

Not yet investigated

What we have so far

Narcolepsy type 1 is the loss of these neurons; the newest sleep drugs block their receptors.

This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.

What we are reading

Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.

  1. Jacobson LH, Hoyer D, de Lecea L. Hypocretins (orexins): The ultimate translational neuropeptides.J Intern Med · 2022 · 291(5):533–55610.1111/joim.13406 · PMID 35043499

    Review. Confirms both halves of the node: loss of hypocretin cells in humans causes narcolepsy type 1 with cataplexy, and that causal link produced a drug class — suvorexant and lemborexant approved for insomnia, daridorexant then filed.

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The full citation list for each investigation, the studies that didn't make the episode, and any corrections — sent the morning it publishes.

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