Sleep & circadian
Rises through every waking hour, falls in sleep; caffeine blocks its receptors.
Not yet investigated
Rises through every waking hour, falls in sleep; caffeine blocks its receptors.
This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.
What we are reading
Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
Review. Adenosine is now accepted as an endogenous sleep-regulatory substance and caffeine acts as its receptor antagonist. The authors are careful that a DIRECT role in sleep homeostasis is still argued, and that acute and chronic caffeine differ — worth keeping when the episode is written.
Connected on the map
Also in Sleep & circadian
The letter
The full citation list for each investigation, the studies that didn't make the episode, and any corrections — sent the morning it publishes.
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