Cardiometabolic
Trimethylglycine donates a methyl group to recycle homocysteine back to methionine — a second route when the folate one is blocked.
Not yet investigated
Trimethylglycine donates a methyl group to recycle homocysteine back to methionine — a second route when the folate one is blocked.
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Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
100 adults, 12 weeks, randomised and double-blind. 400 µg folic acid + 8 mg B6 + 6.4 µg B12 + 1 g betaine cut plasma homocysteine by 10.1% against placebo, and the fall tracked the rise in BOTH folate and betaine — evidence the betaine arm contributed rather than riding on the folate. Two things to keep honest: this was a COMBINATION, so it cannot isolate betaine; and the population was Chinese adults free of mandatory folic acid fortification, so the effect in a fortified country may be smaller. Note also an author affiliation with BYHEALTH, a supplement company.
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