Glycemic control
Insulin-mimetic in animals, and toxic at the doses that did it. The clearest example on this map of a mechanism that never became a medicine.
Not yet investigated
Insulin-mimetic in animals, and toxic at the doses that did it. The clearest example on this map of a mechanism that never became a medicine.
This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.
What we are reading
Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
Review, Polish language, no DOI — find an English primary source before broadcast. The pharmacology is the story and it cuts both ways. Vanadium inhibits protein tyrosine phosphatases, which is genuinely insulin-mimetic: more GLUT-4 at the membrane, more glycogen synthesis, less gluconeogenesis. But the authors state the therapeutic window is VERY NARROW, and that at only a few micromoles the same compounds inhibit cell proliferation and cause apoptosis, necrosis and inflammation. A supplement whose effective dose sits next to its cytotoxic dose is not a supplement.
Connected on the map
Also in Glycemic control
The letter
The full citation list for each investigation, the studies that didn't make the episode, and any corrections — sent the morning it publishes.
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