Pooling 25 trials and 16,037 acutely ill adults, MORE oxygen raised in-hospital mortality by 21%. The harm appears to start around a saturation of 94 to 96 per cent.
Filed under ConceptConstellation Oxygen & breathingStatus Upcoming
Not yet investigated
What we have so far
Pooling 25 trials and 16,037 acutely ill adults, MORE oxygen raised in-hospital mortality by 21%. The harm appears to start around a saturation of 94 to 96 per cent.
This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.
What we are reading
Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.
Chu DK, Kim LH-Y, Young PJ, et al. Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis.Lancet · 2018 · 391(10131):1693–170510.1016/S0140-6736(18)30479-3 · PMID 29726345
25 RCTs, 16,037 patients. In-hospital mortality RR 1.21 (1.03–1.43), 30-day 1.14 (1.01–1.29), longest follow-up 1.10 (1.00–1.20), I² = 0%, GRADE high. The trials span sepsis, stroke, trauma, MI and cardiac arrest — heterogeneous populations, homogeneous result, which is the striking part. The longest-follow-up CI touches 1.00.
