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Longevity & NAD

Glycine:methionine ratio

Muscle meat is rich in methionine and poor in glycine; skin, bone and connective tissue carry the balance. The ratio, not the protein, may be what matters.

Filed under Concept Constellation Longevity & NAD Status Upcoming

Not yet investigated

What we have so far

Muscle meat is rich in methionine and poor in glycine; skin, bone and connective tissue carry the balance. The ratio, not the protein, may be what matters.

This star is on the map because the show intends to take the question apart properly — the trials, how it is actually tested, whether the thing sold is the thing studied. That work is not done yet, and nothing here should be read as a conclusion. When the investigation is published it will appear on this page.

What we are reading

Gathered for the investigation and not yet written up. Each note says what the paper does and does not show.

  1. Holeček M. Glycine as a conditionally essential amino acid and its relationship to l-serine.Metabolism · 2025 · 170:15633010.1016/j.metabol.2025.156330 · PMID 40527450

    Placeholder while the ratio itself is sourced. This review supplies the glycine half — that glycine is only CONDITIONALLY essential, that deficiency is common in ordinary metabolic states, and that one of its consequences is raised homocysteine, which is where methionine metabolism ends up when the recycling routes are short. Still needed before an episode: the methionine-restriction lifespan literature, and human data on whether shifting the dietary ratio changes anything measurable.

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